Retinopathy, Diabetic
About the Disease
Microvascular Complications of Diabetes 5, also known as diabetic retinopathy, is related to microvascular complications of diabetes 1 and type 1 diabetes mellitus. An important gene associated with Microvascular Complications of Diabetes 5 is PON1 (Paraoxonase 1), and among its related pathways/superpathways are ERK Signaling and Signal Transduction. The drugs Mecobalamin and Hydroxocobalamin have been mentioned in the context of this disorder. Affiliated tissues include Eye, and related phenotypes are homeostasis/metabolism and cardiovascular system
Common Targets
G3586 | G4524 | G2322 | Superoxide dismutase (SOD) (nonspecified subtype) | Histone deacetylase (nonspecified subtype) | G762 | G5176 | NADPH Oxidase (nonspecified subtype) | G6934 | P13024 | G339529 | G55328 | G57554 | G3606 | G3767 | G7292 | G25879 | G9290 | P48131 | G84937 | G1124 | G1232 | G6524 | G5243 | G53942 | G930 | G1644 | G7223 | G23254 | G7124 | G83596 | G9054 | G1071 | G3363 | G7422 | G23178 | G1535 | G221692 | G6647 | G4982 | Na+/H+ Exchanger (NHE) (nonspecified subtype) | G4040 | P16683 | G7515 | G57124 | G114299 | G114548 | Nuclear factor of activated T-cells (nonspecified subtype) | G6714 | G25817 | P5768 | G79184 | G9170 | G596 | G4008 | G1012 | G2048 | G814 | G3576 | G221322 | G4804 | G3791 | Vascular endothelial growth factors (VEGF) (nonspecified subtype) | G10123 | G8447 | G4157 | G8568 | P18508 | G6752 | G80704 | G3077 | G441478 | G3717 | G105377555 | G100526739 | G5590 | G6561 | G10800 | G3553 | Tyrosine-Protein Kinases Src (nonspecified subtype) | G732275 | G3673 | G6774 | G241 | G105377662 | G3551 | G5582 | G407040 | G7015 | G406928 | G10587 | G112616 | Thyroid hormone receptor (nonspecified subtype) | G140823 | G7424 | G1902 | G127700 | G6677 | G22941 | G57462 | P5755 | G2053 | G9370 | G3091 | Heat shock protein 90 (nonspecified subtype) | G114803 | G3386 | G8322 | G843 | G2645 | G1520 | G5578 | G3569 | G10628 | G6093 | G81620 | G29102 | Somatostatin receptor (nonspecified subtype) | G187 | Folate Receptor (nonspecified subtype) | G6446 | G11096 | G3274 | G6272 | G7224 | G1514 | G1636 | G1269 | G4049 | G783 | G2898 | G6510 | G5465 | Protein Kinase B (PKB/Akt) (nonspecified subtype) | G3479 | G558 | G7040 | Matrix Metalloproteinase (MMP) (nonspecified subtype) | G1432 | Lipoxygenase (nonspecified subtype) | G2688 | G100874095 | G1950 | Fibroblast growth factor (FGF) (nonspecified subtype) | Phosphatidylinositol 3-kinase (PI3K) (nonspecified subtype) | Integrin Receptor (nonspecified subtype) | P12327 | G25828 | Protein kinase C (nonspecified subtype) | G8224 | G6868 | G286006 | G105369456 | G5654 | G7099 | G2022 | G136 | P6058 | G100287329 | G29106 | G196740 | G79054 | G219621 | G3156 | G1289 | G1723 | Gap junction Connexin ( (nonspecified subtype) | G2050 | G10797 | G2739 | G10131 | G114826 | G3815 | G1813 | G4092 | G3383 | G7852 | G3276 | G23677 | Integrin alphaIIbbeta3 (fibrinogen gpIIb/IIIa) receptor | P5762 | G440275 | G11155 | G2056 | G1490 | G1268 | G6403 | G51393 | G285 | G10801 | G5583 | P5756 | G6648 | G3643 | G285600 | G84898 | G101928273 | G5467 | G1984 | G1994 | G1803 | G142 | G727982 | G231 | G2899 | P16126 | G5580 | G10631 | G11156 | G340895 | G81034 | G3159 | G9927 | G6754 | Tyrosine Kinase (nonspecified subtype) | G8829 | G7442 | G7046 | G5159 | G6262 | G7498 | G5054 | G5770 | G6732 | G140 | G4609 | G90 | G2833 | G94 | G445815 | G5468 | G57007 | Kallikrein (nonspecified subtype) | G823 | Platelet-Derived Growth Factor (PDGF) (nonspecified subtype) | P2X Receptor (nonspecified subtype) | G6387 | G2346 | G64101 | beta-Adrenoceptor (nonspecified subtype) | Glycogen synthase kinase 3 (GSK-3) (nonspecified subtype) | G4914 | G2846 | G8644 | G112869 | G9662 | P12328 | G157310 | G2057 | G2475 | G2690 | G3480 | G5345 | P5753 | Vascular endothelial growth factor receptor (VEGFR) (nonspecified subtype) | G6750 | G6927 | G2444 | G5787 | G623 | G3630 | L-Type calcium channel (nonspecified subtype) | G64135 | Platelet-Derived Growth Factor Receptor (nonspecified subtype) | G6652 | G3263 | G328 | G2697 | G6513 | Poly [ADP-ribose] polymerase (nonspecified subtype) | G2358 | G5579 | G3690 | G7871 | G2321 | G57105 | G221468 | G1024 | G7010 | G4318 | G2764 | G5754 | G6523 | G760 | G7941 | G4846 | G64928 | G105376640 | G2160 | G9475 | G406913 | Large Conductance BK(Ca) Potassium Channel (Maxi K+ Channel) (nonspecified subtype) | G10988 | Focal Adhesion Kinases (FAK) (nonspecified subtype) | G10371 | G2548 | G10194 | G6755 | G50508 | G5588 | G10855 | Gap Junction Protein (nonspecified subtype) | Endothelin receptor (nonspecified subtype) | P5754 | G4067 | G2908 | G9586 | G7350 | G8654 | G375612 | G3818 | G185 | G407051 | G11082 | G4005 | G177 | G6751 | G4567 | G4864 | G342184 | G6121 | G64840 | G4313 | G8811 | G961 | P6884 | G266722 | G8419 | P5759 | G7421 | G4843 | G58504 | G4233 | G6347 | G8989 | G3458 | P24924 | G1585 | G2064 | G5581 | G1234 | G3667 | G5737 | Melanocortin receptor (nonspecified subtype) | Rho kinase (ROCK) (nonspecified subtype) | G105372760 | Glutathione peroxidase (nonspecified subtype) | G406884 | G2621 | G1901 | Defensin (nonspecified subtype) | G1719 | G4161 | G5156 | G302 | P5767 | G387 | G7351 | G2247 | G2740 | G8639 | G824 | P10999 | G10085 | G100506023 | G9772 | G2161 | G23097
The "Target / Biomarker Review Report" is a comprehensive and customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about the Target(s) / Biomarker(s) of your choice related to Retinopathy, Diabetic, including but not limited to:
• general information;
• protein structure and compound binding;
• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
• related patent analysis;
• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
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